This study explores the feasibility of utilizing palm oil fuel ash (POFA) and gypsum powder (GP) as partial replacements for cement in self-compacting concrete (SCC). Various proportions of POFA (20%) and GP (5%, 10%, 15%) were examined to assess their impact on the material and fresh properties of SCC. Physical properties of raw materials were determined, revealing differences in specific gravity and water absorption. Microstructural analysis using Scanning Electron Microscope (SEM) with Energy Dispersive X-Ray Analysis (EDX) indicated higher silica content in POFA (5.96%) and increased calcium content in GP (18.78%). Fresh properties tests, including slump flow, T500, J-Ring, and segregation, demonstrated that the 20P 0GP mix achieved optimal workability and self-compatibility without external compaction. The study highlights the potential of using agricultural waste and natural resources as sustainable alternatives in SCC production.